the effects of nigella sativa hydro-alcoholic extract on memory and brain tissues oxidative damage after repeated seizures in rats

regarding the therapeutic properties of nigella sativa (ns), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (ptz) - induced repeated seizures.there were 4 experimental groups including: 1- control group; received saline, 2- ptz group ; received saline and ptz (50 mg/kg, i.p) , 3-ptz- ns 200 and 4- ptz- ns 400 ; received 200 and 400 mg/kg of ns extract respectively, before ptz injection in 5 consecutive days. seizure scores were lower in ptz – ns 200 and 400, furthermore the seizure onset latencies were higher in these groups than ptz group (pit is concluded that the hydro-alcoholic extract of ns posses beneficial effects on learning and memory impairments in repeated seizures model which is accompanied by antioxidant effects in the brain.